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Journal of Medical Sciences
  Year: 2004 | Volume: 4 | Issue: 2 | Page No.: 158-163
DOI: 10.3923/jms.2004.158.163
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Cataractogenic Potential of Bromate-Mediated Oxidative Stress in Rabbits

N.P. Okolie and J.C. Ikewuchi

The effects of bromate-induced oxidative stress on some cataractogenic indices were studied in the lens, cornea and retina of New Zealand White rabbits given 60 mg kBrO3/kg body wt/day by gavage for 28 days using gravimetric, enzymatic, colorimetric and spectrophotometric procedures. The bromate treatment led to significant decreases in the activities of Na+-K+-ATPase in the lens and cornea and significant increases in corneal catalase and lenticular superoxide dismutase, SOD activities (p<0.05). However the retinal enzymes were unaffected. Significant reductions in the antioxidant vitamins A and C were accompanied by significant elevation of malondialdehyde, MDA in all the tissues investigated (p<0.05). These results are strongly indicative of bromate-induced oxidative stress. The elevation of SOD and catalase activities appear to be adaptive responses to cope with this challenge. The implication of these findings for cataractogenesis and the likelihood of existence of tissue-specific reactive species in bromate-induced oxidative stress in ocular tissues are discussed.
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How to cite this article:

N.P. Okolie and J.C. Ikewuchi , 2004. Cataractogenic Potential of Bromate-Mediated Oxidative Stress in Rabbits. Journal of Medical Sciences, 4: 158-163.

DOI: 10.3923/jms.2004.158.163






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