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Journal of Medical Sciences
  Year: 2004 | Volume: 4 | Issue: 2 | Page No.: 110-114
DOI: 10.3923/jms.2004.110.114
 
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Evaluation of the Cytotoxic and Genotoxic Potential of Khat (Catha edulis Forsk) Extracts on Human T Lymphoblastoid Cell Line

S.S. Barkwan, C.R. Barnett , Y.A. Barnett , P.T. Tomkins and C.N. Fokunang

Abstract:
This paper reports on an investigation of the cytotoxic and genotoxic potential of khat extract using a human T lymphoblastoid cell line (CEM). Exponentially growing CEM cells were cultured for 12 h in the presence of khat extract (0-2000 μg ml-1). Statistically significant, dose-dependent increases in; CEM cell death at dose (> 400 μg ml-1), in DNA damage at dose (>200 μg ml-1) and in micronuclei frequency, at dose (>200 μg ml-1) were observed. The genetic damage effects of khat extract on human cell line observed in this study could serve as a major contribution towards the understanding and creating of awareness of an increased risk of cancer amongst long-term khat consumers.
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How to cite this article:

S.S. Barkwan, C.R. Barnett , Y.A. Barnett , P.T. Tomkins and C.N. Fokunang , 2004. Evaluation of the Cytotoxic and Genotoxic Potential of Khat (Catha edulis Forsk) Extracts on Human T Lymphoblastoid Cell Line. Journal of Medical Sciences, 4: 110-114.

DOI: 10.3923/jms.2004.110.114

URL: https://scialert.net/abstract/?doi=jms.2004.110.114

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