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Journal of Medical Sciences
  Year: 2002 | Volume: 2 | Issue: 1 | Page No.: 35-37
DOI: 10.3923/jms.2002.35.37
 
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Chemical Status of Glutathione in the Presence of a Salicylic Acid Derivative and its Copper Complex

Amir Badshah, Mohammad Farid Khan , Bashir Ahmad , Shumaila Bashir and Gul Majid Khan

Abstract:
The objective of this investigation was to determine the chemical status of Glutathione (GSH) in the presence of a drug and its copper complex employing simple spectrophotometric analysis. A salicylic acid derivative, 3, 5-di-isopropyl salicylic acid (3,5-DIPS) and its copper complex, tetrakis-μ-3,5-di-isopropylsalicylato-diaquodicopper (II) [Cu (II)2 (3,5-DIPS)4.2H2O] was used as a model drug and its complex, respectively. A prominent and regular decrease in the level of GSH was caused by Cu (II)2 (3,5-DIPS)4 2H2O as compared to the simple ligand 3, 5-DIPS. The decrease in the levels of GSH was found to be dependant upon the concentration and time of the Cu (II)2 (3,5-DIPS)4 2H2O. Some changes in the status of GSH might be the basis of this chemical change observed in the form of depletion.
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How to cite this article:

Amir Badshah, Mohammad Farid Khan , Bashir Ahmad , Shumaila Bashir and Gul Majid Khan , 2002. Chemical Status of Glutathione in the Presence of a Salicylic Acid Derivative and its Copper Complex. Journal of Medical Sciences, 2: 35-37.

DOI: 10.3923/jms.2002.35.37

URL: https://scialert.net/abstract/?doi=jms.2002.35.37

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