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Journal of Medical Sciences
  Year: 2002 | Volume: 2 | Issue: 1 | Page No.: 29-31
DOI: 10.3923/jms.2002.29.31
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Kinetics Parameters of Na+, K+-ATPase from Different Mice Brain Lobes

T. A. Kumosani

The kinetic properties of Na+, K+-ATPase from different lobes of swiss albino mice brain were studied under conditions of enzyme saturation with Mg-ATP (0.25-10 mM). By participating in the regulation of ion and voltage gradients, the Na-K pump (Na+, K+-ATPase) influences many aspects of cellular physiology. The apparent Michaelis constant (Km) (Mm) and the apparent maximum velocity (Vmax) (n mol Pi min-1 mg protein) for mice brain lobes Bl-B5 were as follows (0.57; 616), (1.45; 848), (8.44; 7634), (3.19; 95) and (3.34; 110), respectively. The specific activity of lobe B3 has the highest followed by B2, B1, B5 and B4 in decreasing order of activity. It seems that each brain lobe has its own Michaelis constant (Km) and maximum velocity (Vmax) that is needed for their own physiological role. Differences in kinetic properties of Na, K-ATPase from different brain lobes may be due to the isoenzyme diversity and adaptations to specific physiological demands of the specific brain regions.
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How to cite this article:

T. A. Kumosani , 2002. Kinetics Parameters of Na+, K+-ATPase from Different Mice Brain Lobes. Journal of Medical Sciences, 2: 29-31.

DOI: 10.3923/jms.2002.29.31






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