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Journal of Medical Sciences

Year: 2002 | Volume: 2 | Issue: 4 | Page No.: 194-197
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Authors

Susi Endrini

Asmah Rahmat

Patimah Ismail

Taufiq-Yap Yun Hin

Keywords

Research Article

Anticarcinogenic Properties and Antioxidant Activity of Henna (Lawsonia inermis)

Susi Endrini, Asmah Rahmat, Patimah Ismail and Taufiq-Yap Yun Hin
The research was conducted to examines the anticarcinogenic properties of henna (Lawsonia inermis) extract (using chloroform as a solvent) by the microculture tetrazolium salt (MTT) assay on the human breast (dependent-hormone, MCF-7; non-dependent hormone, MDA-MB-231), colon (Caco-2), liver (HepG2) carcinoma cell lines and normal human liver cell lines (Chang Liver). The preliminary results showed that the henna extract displayed the cytotoxic effects against HepG2 and MCF-7 with IC50-value of 0.3 and 24.85 μg ml-1, respectively. However, no IC50 values were obtained from Caco-2 and MDA-MB-231 cell lines at the concentration studied. This extract also did not show the IC50 value against normal human liver cell lines, Chang Liver, indicated the selectivity of its cytotoxic properties. The antioxidative activities of this extract which could contribute to its cytotoxic properties were also studied. Antioxidant activity in henna was found to be the highest as compared to vitamin E or α -tocopherol. The strong cytotoxic properties of this extract could be due to its high antioxidant activities.
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