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Journal of Medical Sciences
  Year: 2002 | Volume: 2 | Issue: 4 | Page No.: 177-181
DOI: 10.3923/jms.2002.177.181
 
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Implications of Nitric Oxide and Carbon Monoxide in Neonatal Sepsis

Shadia El-Sallab, Hesham Abdel-Hady , Ekbal Abu-Hashim and Mohamed Matter

Abstract:
Nitric oxide (NO) and carbon monoxide (CO) are proposed to regulate physiologic vascular tone, blood pressure, and tissue perfusion. To investigate their role in the pathogenesis of neonatal sepsis, plasma levels of NO and CO in 45 neonates with clinical evidence of sepsis plus positive blood culture as well as in 20 healthy neonates were assessed. Significantly higher plasma levels of NO and CO in sepsis group compared with control group were found (56.4 ± 21.1 vs. 33.4 ± 12.1 Fmol L-1, p < 0.0001; 44.0 ± 12.0 vs 23.7 ± 8.5 nmol L-1, p < 0.0001, respectively). This increase in NO and CO levels occurred independent of gestational age, onset of sepsis, and gram stain of the isolated organism. Moreover, there were significantly higher plasma levels of NO and CO in septic infants who required inotropic support compared with those who did not require this support (p<0.0001). Plasma CO was higher in non-survivors compared with survivors (p=0.003). Significantly positive correlation between plasma NO and CO was observed. In conclusion, plasma NO and CO was increased in neonatal sepsis. This increase is independent of gestational age, onset of sepsis and gram stain of the isolated organism. Assay of plasma CO and NO may help to assess the severity of sepsis and progression to septic shock. The role of nitric oxide synthase (NOS) and heme oxygenase (HO) inhibitors in the management of neonatal sepsis should be investigated in further trials.
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How to cite this article:

Shadia El-Sallab, Hesham Abdel-Hady , Ekbal Abu-Hashim and Mohamed Matter , 2002. Implications of Nitric Oxide and Carbon Monoxide in Neonatal Sepsis. Journal of Medical Sciences, 2: 177-181.

DOI: 10.3923/jms.2002.177.181

URL: https://scialert.net/abstract/?doi=jms.2002.177.181

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