Study of Protein Binding of Levofloxacin in Human Beings

Research Article

Study of Protein Binding of Levofloxacin in Human Beings

Sheikh, M.A., S. Khanum, A. Ahmad, T. Iqbal, Z. Hydair and Shakeela Naz

Levofloxacin is a quinolone antimicrobial which acts through the inhibition of bacterial topoisomerases that has been developed mostly for clinical use in human medicine. Its protein binding was investigated in human beings under indigenous conditions. Drug concentration of 1, 2, 3, 4 and 5 g/ml were added to the plasma and binding of levofloxacin was determined by ultrafiltration and its concentration in ultrafiltrates was determined by microbiological assay. The binding of levofloxacin showed positive correlation between drug concentration and percentage bound drug and maximum binding was observed at 5 g/ml and 59% in human beings. The pH of plasma also affected the binding, being highest at 7.4 in human beings, and it was 53%. In vitro binding of levofloxacin was maximum at normal level of blood protein.

PDF Fulltext XML References Citation

How to cite this article

Sheikh, M.A., S. Khanum, A. Ahmad, T. Iqbal, Z. Hydair and Shakeela Naz, 2001. Study of Protein Binding of Levofloxacin in Human Beings. Journal of Medical Sciences, 1: 87-90.

DOI: 10.3923/jms.2001.87.90

URL: https://scialert.net/abstract/?doi=jms.2001.87.90

Journal of Medical Sciences

Article Trend

Total views 195

Authors

Sheikh, M.A.

S. Khanum

A. Ahmad

T. Iqbal

Z. Hydair

Shakeela Naz

Keywords

Research Article

Study of Protein Binding of Levofloxacin in Human Beings

How to cite this article

Related Articles

Leave a Comment