
	Journal of Medical Sciences
	Year: 2001 \| Volume: 1 \| Issue: 6 \| Page No.: 368-371 DOI: 10.3923/jms.2001.368.371

Toxicological Studies of Two Novel Compounds Isolated from Streptomyces Species

A. S. M. Anisuzzaman , Naoki Sugimoto , M. S. A. Bhuiyan , Golam Sadik and M. A. Gafur

Abstract: The chloroform extract and the two novel compounds streptmysone-A (I) and streptomysone-B (II) of the Czapek-Dox (alkaline) culture filtrate of the Streptomyces species were studied for cytotoxic and acute toxicity activities. The cytotoxic activity of the compounds and the extract was determined by brine shrimp lethality bioassay while the acute toxicity study was performed on Swiss albino mice. The LC₅₀ values of chloroform extract(CHCl₃), compound (I) and (II), and standard ampicillin trihydrate were found to be 3.89, 6.31, 125.8 and 6.31Fg ml^-1, respectively. The LD₅₀ values were found to be 66.34 and 79.49mg kg^-1 for the compound (1) and (II), respectively.

PDF Fulltext XML References Citation Report Citation

How to cite this article:

A. S. M. Anisuzzaman , Naoki Sugimoto , M. S. A. Bhuiyan , Golam Sadik and M. A. Gafur , 2001. Toxicological Studies of Two Novel Compounds Isolated from Streptomyces Species. Journal of Medical Sciences, 1: 368-371.

DOI: 10.3923/jms.2001.368.371

URL: https://scialert.net/abstract/?doi=jms.2001.368.371

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		EMBASE
		Google Scholar
		SCIMAGO

Science Alert