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Journal of Medical Sciences

Year: 2001 | Volume: 1 | Issue: 6 | Page No.: 361-367
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Authors

Gul Majid Khan

Jia-Bi Zhu

Keywords

Research Article

Evaluation of Ethocel® Premium Ethylcellulose Ether Derivatives with Different Molecular Weights as Controlled-release Matrix Forming Functional Polymers for Ibuprofen

Gul Majid Khan and Jia-Bi Zhu
This research work was promoted by the desire to investigate and compare the potentials of conventional granular Ethocel® Premium and Ethocel® Standard FP Premium (the latest in the ethylcellulose ether family) as controlled-release (CR) hydrophobic matrix forming functional polymers for ibuprofen (IBF), a sparingly water-soluble, anti-inflammatory agent. IBF- Ethocel® CR matrix tablets were prepared by direct compression as well as by wet granulation methods. The influence of several parameters such as polymer type, molecular weight (viscosity grade), and particle size; drug-to-polymer (D:P) ratio; and preparation methodology of the matrices on the physical characteristics of the granulations as well as the tablets and IBF release rates from the matrix tablets were investigated. The dissolution equivalency of the release profiles from the formulations investigation were determined making the use of f2-metric technique by fitting the release profiles data into the f2-metric equation using a computer program. Granular Ethocel® polymers with lower viscosity grades demonstrated greater compressibility and lower release rates than those with higher viscosity grades. Ethocel® standard FP Premium polymers exhibited greater efficiency in controlling the release of IBF from the matrices as compared to the granular conventional Ethocel® polymers. Moreover, polymer level and particle size, rather than viscosity grade of the polymers, were found to be determining factors in controlling the drug release rates. Furthermore, matrices prepared by wet granulation showed more efficient control to retard the drug release rates than those prepared by direct compression method.
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