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| Controlled Release Coprecipitates of Ibuprofen and Carbopol® 934p-NF: Preparation, Characterization and in Vitro Drug Release |
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Gul Majid Khan and Jia-Bi Zhu |
Abstract:
Extended release coprecipitates of ibuprofen (IBF) and Carbopol 934P-NF, in the
form of micro-matrices, were prepared using two different methods. The drug-carbomer interactions in the solid state were investigated employing, Scanning
Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC) and Infra Red
(I R) Spectroscopy. Dissolution experiments were performed using simulated gastric
fluid (SGF; pH 1.2), distilled water and pH 7.2 phosphate buffer solution as
dissolution media. No well-defined chemical interaction was found between the
constituents of coprecipitate. The methods of preparation of the coprecipitates are
simple and practical. Both of them minimize the use of toxic organic solvents and
have very promising potentials to be used in the production of controlled release
tablets.
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