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Journal of Medical Sciences
  Year: 2001 | Volume: 1 | Issue: 5 | Page No.: 327-333
DOI: 10.3923/jms.2001.327.333
 
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Synthesis and Characterization of Some Novel Tranexamic Acid Derivatives and Their Copper (II) Complexes

Muhammad Fayyaz Khan, Mohammad Farid Khan , Muhammad Ashfaq and Gul Majid Khan

Abstract:
The objective of this investigation was to synthesize and characterize some substitutive derivatives of Tranexamic Acid (TA) and their copper (II) complexes. N-Phthaloyltranexamic Acid (A-1), N-Acetyltranexamic Acid (A-2), Di-Tranexamate Diaquo Copper (II) (C-1), Di-N-Phthaloyltranexamate Diaquo Copper (II) (C-2) and Di-N-Acetyltranexamate Diaquo Copper (II) (C-3) were synthesized, using novel and reproducible procedures. These compounds were characterized by exploiting the techniques such as Fourier Transform Infra Red (FTIR) Spectroscopy, Mass Spectroscopy (MS) and FT 1H NMR. Different methods, reported in the literature, have successfully been applied for qualitative and structural characterization of these compounds. C-1 showed unidentate bonding of carboxylic group to copper (II) while C-2 and C-3 indicated bidentate bonding of carboxylate group to copper (II).
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How to cite this article:

Muhammad Fayyaz Khan, Mohammad Farid Khan , Muhammad Ashfaq and Gul Majid Khan , 2001. Synthesis and Characterization of Some Novel Tranexamic Acid Derivatives and Their Copper (II) Complexes. Journal of Medical Sciences, 1: 327-333.

DOI: 10.3923/jms.2001.327.333

URL: https://scialert.net/abstract/?doi=jms.2001.327.333

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