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Journal of Medical Sciences

Year: 2001 | Volume: 1 | Issue: 4 | Page No.: 193-199
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Authors

Gul Majid Khan

Farmanull Wazir

Jia-bi Zhu

Keywords

Research Article

Ibuprofen-cyclodextrin Inclusion Complexes: Evaluation of Different Complexation Methods

Gul Majid Khan, Farmanull Wazir and Jia-bi Zhu
The objective of this study was to investigate the influence of temperature on the optimization process of the formation of inclusion complexes, preparation and characterization of inclusion complexes between ibuprofen (IBF) and β-cyclodextrin (β-CD), and the evaluation of different complexation methods. Inclusion complexes in the solid powdered forms were prepared by homogenous coprecipitation-evaporation (CE), coprecipitation-centrifugation (CC), spray drying (SD), and freeze drying (FD) methods. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), x-ray diffractometry and I R absorption spectroscopy were exploited to characterize the solid complexes. In vitro dissolution experiments were conducted in distilled water using the USP XXII paddle method. The f2-metric technique was employed for the determination of equivalency between the dissolution profiles through multiple linear regression computer soft ware program. Temperature was found to have an important role in the optimization process of the complex formation. A marked difference in the properties of the complexes was observed due to their methods of preparation. In general, the solubility and dissolution rates of the complexes formed were greatly enhanced over that of the physical mixture, which, in turn, could demonstrate higher dissolution rates than those displayed by the pure drug. The freeze drying method was found to provide with the highest dissolution rates among the methods used in this investigation.
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