|
|
| |
Cadmium Induced Toxicity on Pregnant Mice and Their Offspring: Protection by
Magnesium or Vitamin E |
|
Karima Z. Wershana |
Abstract:
The research work was conducted to investigate the toxic effects of cadmium
(Cd+2), administered during gestation period, on female albino mice and their
offspring. A sublethal dose of Cd+2 (0.2mg Cd+2 kg‾1 b.wt, s.c.) was injected to
pregnant mice on daily basis for 10 consecutive days as from the 3rd day of
gestation and they were allowed to deliver normally. Cd+2 induced significant
reduction in litter size, marked elevations in the numbers of dead newborns,
externally malformed newborns per litter and increased the Cd+2 concentrations in
their bodies. Cadmium injection also, caused growth retardation of the offspring
at the day of birth as well as after two and four postnatal weeks. In addition, It
increased their mortality percentages at the day of birth as well as during the first
two postnatal weeks. It induced decreases in erythrocytic counts (RBCs),
hemoglobin contents (Hb) and hematocrit values (packed cell volume, PCV)
along with insignificant changes in mean corpuscular volume (MCV), mean
corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration
(MCHC) for female mice at the day of parturition as well as in their offspring
after two and four postnatal weeks. It also evoked leucocytosis, granulocytosis and
lymphopenia, while monocytes did not show significant alterations. The
administration of Cd+2 induced hepatotoxicity as indicated by elevations in the
activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT)
and alkaline phosphatase (ALP). It, also, caused renal dysfunction as indicated by
obvious rises in the concentrations of urea and creatinine in plasma. Also, this
work aimed to investigate the assessment of the potential protective effect of
either magnesium (Mg+2) (73mg Mg+2 kg‾1 b.wt) or vitamin E (100mg vit. E.
kg‾1 b.wt.). The antidotes were injected as repeated s.c. daily doses starting from
the 1st up to the 18th day of gestation. Magnesium administration prevented
completely all defects that were induced by Cd+2 while vit. E supplementation
exhibited only moderate improvement in these defects. This investigation
demonstrates that Mg+2 is more potent then vit. E in protecting female mice and
their offspring from Cd+2 induced defects. Mg+2 may be a promising protective
agent against Cd+2 intoxication.
|
|
|
PDF
Fulltext
XML
References
Citation
Report Citation
|
|
|
|
| RELATED ARTICLES: |
|
|
|
How to cite this article:
Karima Z. Wershana , 2001. Cadmium Induced Toxicity on Pregnant Mice and Their Offspring: Protection by
Magnesium or Vitamin E. Journal of Medical Sciences, 1: 179-186.
DOI: 10.3923/jms.2001.179.186
URL: https://scialert.net/abstract/?doi=jms.2001.179.186
|
|
|
|
|
| COMMENT ON THIS PAPER |
|
|
|
|
| |
 |
Navigation |
| |
|
|
| |
|
Indexed In |
| |
|
|
Subscribe Today 
