Abstract:
The research work was conducted to investigate the effect of
intragastric administrations (five days a week) of praziquantel in a
dose of 142mg kg-1 body weight (bw) for 85 days and black
pepper in doses of 160 and 320 mg kg-1 bw for 36, 71, and
99 days on liver contents of DNA, total proteins, number and size of
the liver cells and histopathological changes in the liver tissues of
male and female albino rats. Non-significant changes were revealed that
regarding the effect of both praziquantel, on DNA and cell numbers,
and black pepper, on all the studied parameters, in male and female
groups. Significant increase in liver total proteins and cell size was
observed after praziquantel treatments. Modulating potential effect
of black pepper, in a dose of 160mg kg‾1 bw, on the
changed hepatic aspects induced by praziquantel was proved. Hepatic
histopathological studies also showed lower percentage of animals manifesting
moderate pathological changes in the group of animals treated with black
pepper 160 mg kg‾1 bw followed by praziquantel 142mg
kg‾1 bw when compared to the praziquantel group. The
higher dose of black pepper showed the moderate and marked hydropic
degeneration and portal tract inflammation throughout the used intervals
in both male and female groups. The tested doses of praziquantel and
black pepper throughout the used intervals could not cause malignant
transformation, necrosis, or fatty degeneration.
Laila S. Hanna , Samia E. Ali and Hany M. Khattab , 2001. Evaluation of Effect and Modulatory Action of Black Pepper (Piper nigrum) and Praziquantel, Schistosomicidal Drug, On Selected Hepatic Aspects. Journal of Medical Sciences, 1: 147-152.
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