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Research Journal of Microbiology
  Year: 2015 | Volume: 10 | Issue: 8 | Page No.: 377-384
DOI: 10.3923/jm.2015.377.384
 
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Evaluation of Biological Activity of Secondary Metabolites of Neurospora crassa from Machilipatnam Sea Water

K. Ashok Kumar, S.K. Gousia and J. Naveena Lavanya Latha

Abstract:
The aim of present study is to study the anti-bacterial and fungal activities of Neurospora crassa, which is isolated from the marine sample collected from Machilipatnam coast of Andhra Pradesh, India. The fungus was isolated on PDA Media amended with chloramphenicol. Fungus was identified as, N. crassa by morphological and microscopic observations. Isolated fungus was inoculated into liquid medium for secondary metabolites production. Crude extract is characterized for biological activities. The TLC is performed to identify and purify the sub fractions in the extract. The same were tested against different pathogenic bacteria and fungi to determine the antibacterial and anti fungal activities. The study revealed that, among the fungal species used Neurospora crassa was found to be active against all bacterial and fungal strains tested. The collected crude extract of N. crassa showed 24 mm diameter zone against Aspergillus flavus, at concentration of 200 μg and the best activity was observed at a concentration of 200 μg against E. coli and Streptococci which showed 18 mm diameter. The TLC Neurospora crassa crude extract revealed 7 fractions. The selected organism which produces the compounds contains the biological activities, which include, anti-bacterial and anti fungal activities. Hence, we conclude that the compounds have high efficiency of anti microbial activity, which needs extensive attention in terms of new therapy. Neurospora crassa may lead to the discovery of pharmaceutically valuable products.
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How to cite this article:

K. Ashok Kumar, S.K. Gousia and J. Naveena Lavanya Latha, 2015. Evaluation of Biological Activity of Secondary Metabolites of Neurospora crassa from Machilipatnam Sea Water. Research Journal of Microbiology, 10: 377-384.

DOI: 10.3923/jm.2015.377.384

URL: https://scialert.net/abstract/?doi=jm.2015.377.384

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