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Research Journal of Microbiology

Year: 2009 | Volume: 4 | Issue: 4 | Page No.: 164-167
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Authors

Archana A. Bele

Varsha M. Jadhav

S.R. Nikam

Vilasrao J. Kadam

Keywords

Natural drugs are boon to mankind. They have few side effects as compared to allopathic medicine. This invention relates to herbal composition, having potent anti-bacterial and wound healing property. The formulation prepared is a gel, which is used for effective treatment of wounds and exhibits broad spectrum antibacterial action. Crude extracts of Punica granatum pericarp and Curcuma longa showed antibacterial activity against different strains of gram positive such as Staphylococcus aureus, Bacillus subtilis and gram negative microorganisms such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris and Enterobacter aerogenes. The MIC is recorded as the lowest concentration of drug which showed clear fluid without turbidity. Minimum inhibitory concentration of Punica granatum peel ranged from 0.05 to 3.2 mg mL-1 and for Curcuma longa MIC ranged from 5 to 320 mcg mL-1. Formulation containing these extracts, showed significant zone of inhibition for 0.5, 1, 2.5, 5% of which 5% showed maximum zone of inhibition (ranging from 20.2 to 26 mm ) as compared to marketed preparation. The present investigation revealed that gel formulation has potential antibacterial activity.
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