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Journal of Entomology

Year: 2005 | Volume: 2 | Issue: 1 | Page No.: 46-51
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Authors

Z.M. TU

G.Y. He

Chris Gillies

J.T. Zhao

Keywords

Research Article

The Structure, Functions and Evolution of Su (Ste) Repeats on the Y Chromosome of Drosophila melanogaster

Z.M. TU, G.Y. He, Chris Gillies and J.T. Zhao
In recent years, the research on the Y chromosome of Drosophila melanogaster has made great progress. The Y-linked, testis-expressed Su (Ste) repeats are thought to be suppressors of Stellate transcription. New in this study is the recent advance on studies of the structure and functions of Su (Ste) repeat units on Y chromosome; We expressed the hypothesis about the cosuppression mechanism of Su (ste) and Stellate: Su (ste) antisense RNA combined with Stellate RNA to form double strands RNA (dsRNAs), which restrains Stellate expression; Su (ste) sense-chain RNA reacts on Su (ste) anti-sense RNA, to form dsRNA that restrains Su (ste)’ transcription, which called negative autogenously regulation, now we call it RNAi; The mechanism of the Su(Ste) repeats’ suppression on meiotic-driving is also discussed: In the spermatocyte of male Drosophila which delete the Su (ste), Stellate mRNA and Stellate protein were highly expressed, which caused the crystal formation and the change of meiosis, then resulted in the male sterility. The mechanism of how the expression of Stellate protein causing the abnormal of meiotic is possibly because the restrain of gene CK2 activity. The molecular evolution of the Su(ste) repeats has been reviewed in this paper too, the unique testis-expressed euchromatic gene was suggested to be an ancestor of both types of amplified paralogous repeats, SLL originates from CK2 through reverse-transcription, Su(Ste) and Stellate at the same time originate from SLL, then the ancestor sequence translocated to Y- chromosome.
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