Submit Manuscript

Journal of Biological Sciences

Year: 2021 | Volume: 21 | Issue: 1 | Page No.: 1-9
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 332

Authors

Lawson-Evi Povi

Lawson-Evi Povi

A.E. Motto

K. Atchou

K. Tona

K. Eklu-Gadegbeku

K. Aklikokou

Keywords

Background and Objective: Pterocarpus erinaceus (Fabaceae), Amaranthus spinosus (Amaranthaceae) and Anogeissus leiocarpus (Combretaceae) are plants used in the treatment of diabetes many times. The present study was undertaken to observe the insulinomimetic activity of a different type of plants. Materials and Methods: The hypoglycemic effect of hydroalcoholic extracts from the stem bark of P. erinaceus and the roots of A. spinosus and A. leiocarpus was evaluated in ovo on 11 days-old chicken embryos and ex vivo on skeletal muscles isolated from rats. Results: All extracts reduced significantly the chicken embryos basal glycemia in the treated groups compared to the control group at the doses of 0.03 and 0.06 mg/100 μL. The extract of A. leiocarpus (0.5 and 1 mg mL–1) increased (p<0.001 and p<0.0001) the absorption of glucose by the muscle in the presence and absence of insulin more than the extracts of Pterocarpus erinaceus and Amaranthus spinosus. Conclusion: Hence, it was concluded that, the three extracts decreased the basal glycemia in ovo. Whereas the extract of A. leiocarpus has an effect, similar to an insulinomimetic effect.
PDF Fulltext XML References Citation

How to cite this article

Lawson-Evi Povi, A.E. Motto, K. Atchou, K. Tona, K. Eklu-Gadegbeku and K. Aklikokou, 2021. Insulinomimetic Activity Assessment of Antidiabetic Plants Used in Togolese Pharmacopoeia, in ovo and ex vivo Study. Journal of Biological Sciences, 21: 1-9.

DOI: 10.3923/jbs.2021.1.9

URL: https://scialert.net/abstract/?doi=jbs.2021.1.9

Leave a Comment

Your email address will not be published. Required fields are marked *