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Journal of Biological Sciences
  Year: 2020 | Volume: 20 | Issue: 1 | Page No.: 1-6
DOI: 10.3923/jbs.2020.1.6
 
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A Female Wistar Rats Model for Assessing the in vivo Protective Role of Scoparia dulcis on Liver, Kidney and Brain

A.Y. Coulibaly , J.H. Bationo, Fatouma Mohamed Abdoul-Latif, Bakasso Sahabi and M. Kiendrebeogo

Abstract:
Background and objectives: Scoparia dulcis is a medicinal herb traditionally used to relieve dementia disorders in Burkina Faso. A female Wistar rats model was used against hydroacetonic extract of Scoparia dulcis to assess the effect of neuroprotective, hepatoprotective and renoprotective. Materials and Methods: The rats were divided into 5 groups with 6 animals/group. Carboxymethyl cellulose (CMC, 0.5%) was used as vehicle to treat the animals by oral route with silymarin or the plant extract. Seven days later, they were intoxicated by intra-peritoneal injection of carbon tetrachloride (2 mL kg1) for 24 h. Then blood, brain, kidney and liver were taken for further analysis. Results: It resulted on a neuroprotective effect noted by an increase in acetylcholinesterase level, a hepatoprotective effect was also registered with a significant decrease in triglycerides, cholesterol, alanine amino-transferase (ALT), aspartate amino-transferase (AST), superoxide dismutase (SOD) and malondialdehyde (MDA). The renoprotective potential was marked by a decrease of urea, uric acid and creatinine. Conclusions: Scoparia dulcis can be a suitable candidate for investigation of neuroprotective agents.
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How to cite this article:

A.Y. Coulibaly, J.H. Bationo, Fatouma Mohamed Abdoul-Latif, Bakasso Sahabi and M. Kiendrebeogo, 2020. A Female Wistar Rats Model for Assessing the in vivo Protective Role of Scoparia dulcis on Liver, Kidney and Brain. Journal of Biological Sciences, 20: 1-6.

DOI: 10.3923/jbs.2020.1.6

URL: https://scialert.net/abstract/?doi=jbs.2020.1.6

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