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Journal of Biological Sciences

Year: 2019 | Volume: 19 | Issue: 3 | Page No.: 224-230
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Authors

Kasimu Ghandi Ibrahim

Kasimu Ghandi Ibrahim

Eliton Chivandi

Kennedy Honey Erlwanger

Richard Leslie Brooksbank

Keywords

Background and Objective: Telomere lengths are affected epigenetically during stages of developmental plasticity. Whether curcumin and/or fructose administered to pups affects their leucocyte telomere lengths in adolescence following post-weaning a high fructose diet was investigated. Materials and Methods: One hundred and twenty eight suckling pups were gavaged with either a 0.5% DMSO, 500 mg kg–1 curcumin, fructose (20%, w/v) or a combination of curcumin and fructose for 15 days. On post-natal day 21, each of the initial groups was split into two subgroups: One had plain drinking water while the other was provided fructose (20%, w/v) as their drinking fluid for 6 weeks. The body masses of the rats were measured before termination with sodium pentobarbitone (150 mg kg–1, i.p.). Genomic DNA was extracted from whole blood. Relative leucocyte telomere length was determined using real time polymerase chain reaction. Results: The administration of curcumin and or fructose during suckling in Sprague Dawley rat pups, did not have any significant effects (p>0.05, ANOVA) on the body masses and relative leucocyte telomere lengths in both male and female rats across the treatment groups. Conclusion: Curcumin and fructose, though previously shown to have epigenetic effects did not alter the relative leucocyte telomere lengths in the growing rats and may therefore not lead to increased telomere attrition.
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