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Journal of Biological Sciences
  Year: 2018 | Volume: 18 | Issue: 8 | Page No.: 458-467
DOI: 10.3923/jbs.2018.458.467
 
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Protective Role of Seed Extract of Tephrosia purpurea in Letrozole Induced Polycystic Ovary Syndrome in Wistar Rats

Muddasir Basheer , Seema Rai , Hindole Ghosh and Younis Ahmad Hajam

Abstract:
Background and Objective: Polycystic Ovary Syndrome (PCOS) is very common heterogeneous endocrinologic and metabolic disorder in women of reproductive age which leads to infertility/subfertility. The medications available are associated with so many side effects. Therefore; the current study aimed to elucidate the therapeutic efficacy of seed extract of Tephrosia purpurea (TP) in letrozole induced polycystic ovary syndrome (PCOS) in female rat model. Materials and Methods: Letrozole was administered orally (1 mg kg–1 body weight) for 21 days to induce PCOS condition in female rat model (Rattus norvegicus). Three different doses of ethanolic seed extract were administered to PCOS induced rats orally (100, 200 and 300 mg kg–1) for 28 days. On the completion of experimental period, different parameters were studied viz. ovarian weight, ovarian tissue biochemistry (lipid peroxidation, reduced glutathione and superoxide dismutase), hormone assays (testosterone, estrogen, progesterone, FSH, LH, leptin) and histopathology. Results: Ovarian PCOS-induced female rats revealed significant increase in ovarian weight lipid peroxidation and blood plasma testosterone, luteinizing hormone and follicle stimulating hormone when compared to control group, whereas, there was a reduction in the level of blood plasma estradiol, progesterone leptin and ovarian tissue reduced glutathione and superoxide dismutase activities. The ethanolic seed extract restored the anomalies in biochemical, hormonal and histological parameters suggesting it might be used in the management of PCOS. Conclusion: Therefore, it might be suggested that ethanolic seed extract of Tephrosia purpurea might be used in the management of PCOS.
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How to cite this article:

Muddasir Basheer, Seema Rai, Hindole Ghosh and Younis Ahmad Hajam, 2018. Protective Role of Seed Extract of Tephrosia purpurea in Letrozole Induced Polycystic Ovary Syndrome in Wistar Rats. Journal of Biological Sciences, 18: 458-467.

DOI: 10.3923/jbs.2018.458.467

URL: https://scialert.net/abstract/?doi=jbs.2018.458.467

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