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Journal of Biological Sciences
  Year: 2018 | Volume: 18 | Issue: 1 | Page No.: 21-31
DOI: 10.3923/jbs.2018.21.31
 
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Antagonizing the Hazardous Impact of Increased Oxidative Stress in Wistar Rats by Biscuits with Dried Orange Peel
Maha Hanafy Mahmoud , Hany Mohamed Ahmed Wahba , Marwa Hanafy Mahmoud and Ferial Mohamed Abu-Salem

Abstract:
Background and Objective: It is settled nowadays that oxidative stress is a causative factor for many chronic diseases. Increasing intake of natural antioxidants is believed to reduce the negative effect of oxidative stress and decrease the risk for diseases. The present study was designed to evaluate the biological effect of feeding rats on dried orange peel as a rich source for natural antioxidants when being incorporated in biscuits along with sodium nitrite as an inducer for increased oxidative stress. Materials and Methods: The optimum method for orange peel drying without remarkable loss in its antioxidant potency was determined. Polyphenol content for orange peel and antioxidant activity with four different methods were assessed. A biological experiment was done on 24 male Wistar albino rats as four groups which lasted for 5 weeks. The first group was a control negative group fed on control diet. The second was another control group but was fed on 200 g of biscuits with dried orange peel kg–1 diet. The third and fourth groups were fed on a diet containing 7 g sodium nitrite kg–1 diet but 200 g of biscuits with dried orange peel kg–1 diet was mixed with the diet of the fourth group. Results: Evaluation of antioxidant activity and polyphenol content for the three drying methods of orange peel revealed that solar energy was the best drying method. Biochemical analysis revealed that nitrite fed group recorded a significant increase in malondialdehyde, G6PDH, ALT and a non-significant decrease in blood hemoglobin, the activity of catalase and SOD. Also, a significant decrease in body weight gain, feed intake and feed efficiency ratio was noticed for the same group. These parameters were restored in the group of rats that was fed on biscuits with dried orange peel along with sodium nitrite. Conclusion: Feeding rats on dried orange peel which was dried with solar energy and included in biscuits with their diet was able to antagonize the hazardous effect of increased oxidative stress due to sodium nitrite. So, it is recommended to incorporate orange peel in our food like biscuits to protect us from the increased oxidative stress.
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How to cite this article:

Maha Hanafy Mahmoud, Hany Mohamed Ahmed Wahba, Marwa Hanafy Mahmoud and Ferial Mohamed Abu-Salem, 2018. Antagonizing the Hazardous Impact of Increased Oxidative Stress in Wistar Rats by Biscuits with Dried Orange Peel. Journal of Biological Sciences, 18: 21-31.

DOI: 10.3923/jbs.2018.21.31

URL: https://scialert.net/abstract/?doi=jbs.2018.21.31

 
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