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Journal of Biological Sciences

Year: 2017 | Volume: 17 | Issue: 2 | Page No.: 69-75
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Authors

Fatemeh Mehdipour

Nader Shahrokhi

Khadijeh Esmaeilpour

Taj Pari Kalantaripour

Hakime Oloumi

Mohsen Basiri

Majid Asadi-Shekaari

Keywords

Background: Date (Phoenix dactylifera L.) is an important plant in some of Asia and Africa. The importance of date fruit in human nutrition comes from its valuable components such as vitamins, carbohydrates, dietary fibers, salts and proteins. Data have been shown that Aqueous Date Fruit Extract (ADFE) has protective effects in different models of neuronal disorders. Alzheimer’s Disease (AD) is a type of dementia that causes problems with thinking, memory and behavior. Symptoms generally develop slowly and get worse over time, becoming severe enough to interfere with daily tasks. In the current study, the effects of ADFE treatment on cognitive impairments and neural degeneration in animal model of AD was investigated. Methodology: Adult male rats were divided into three experimental groups including: β-amyloid group that received β-amyloid 25-35 (3 μL) through ICV injection, sham group that undertook the same surgical procedures as β-amyloid group, treated with vehicle (distilled water) and ADFE group was ICV injected with β-amyloid 25-35 and treated with ADFE for 12 consecutive days (4 mL kg–1, gavage). Cognitive behavioral analysis has been performed by Morris Water Maze (MWM) test. Also, neuronal degeneration and cell apoptosis examination was calculated by routine staining as well as TUNEL assay. Results: The results of this experimental study revealed that ADFE improves learning process in β-amyloid induced impairments in male rats, however, it could not ameliorate the memory process and neural degeneration. Conclusion: This finding may be due to disruption in glucose and insulin regulation in AD and hyperglycemia induced by the ADFE administration.
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How to cite this article

Fatemeh Mehdipour, Nader Shahrokhi, Khadijeh Esmaeilpour, Taj Pari Kalantaripour, Hakime Oloumi, Mohsen Basiri and Majid Asadi-Shekaari, 2017. Aqueous Date Fruit Extract can’t Ameliorate β-amyloid Induced Memory Impairments in Male Rats. Journal of Biological Sciences, 17: 69-75.

DOI: 10.3923/jbs.2017.69.75

URL: https://scialert.net/abstract/?doi=jbs.2017.69.75

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