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Journal of Biological Sciences
  Year: 2017 | Volume: 17 | Issue: 6 | Page No.: 255-266
DOI: 10.3923/jbs.2017.255.266
Prevention from Complications Associating Liver Toxicity by Carbon Tetrachloride Using a Blend of Plants in the Form of Dietary Supplement
El-Shobaki F.A. , Amal S. Abdel-Azeem , Amany M. Hegazy and I.H. Badawy

Abstract:
Background and Objective: Carbon tetrachloride toxicity has been reported to cause several hepatocellular pathological changes. The present study was designed to investigate the efficiency of 2 formulas formed from several plant sources to protect against the health complications associating liver toxicity due to carbon tetrachloride injection. Materials and Methods: In this study 2 dietary supplements, the first constituted of green apple (25%), pomegranate (25%), red grape (25%), green tea (10%), tomato (10%) and artichoke (5%), the second of green tea (15%), licorice (25%), mint (25%), coffee (5%), lemon (15%) and grape fruit (15%) were used. The results were statiscally analyzed using SPSS-PC software, version 22. One-way analysis of variance (ANOVA) was used for comparison of different biochemical values. Results: Rats injected with carbon tetrachloride (1 mL kg–1 b.wt.) showed a significant decrease of serum protein and albumin, the activities of AST, ALT, γ-GT and ALP were significantly increased. Significant increase in most lipid parameters occurred while the high density lipoprotein was decreased. The antioxidant capacity of the 2 formulas were high. Inclusion of each of these 2 formulas with the diet of injected rats prevented most of the associated health complications as indicated by sound correction of most biochemical parameters describing the biochemical changes that occurred due to carbon tetrachloride injection, however the correction of the histopathological changes that occurred due to carbon tetrachloride injection was limited. Conclusion: It was recommended to use these 2 dietary supplements by patients suffering from liver diseases assuming that they will help a lot to ameliorate health complications associating the liver disease thus act as complementary medicine to the main route of therapy.
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How to cite this article:

El-Shobaki F.A., Amal S. Abdel-Azeem, Amany M. Hegazy and I.H. Badawy, 2017. Prevention from Complications Associating Liver Toxicity by Carbon Tetrachloride Using a Blend of Plants in the Form of Dietary Supplement. Journal of Biological Sciences, 17: 255-266.

DOI: 10.3923/jbs.2017.255.266

URL: https://scialert.net/abstract/?doi=jbs.2017.255.266

 
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