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Journal of Biological Sciences

Year: 2016 | Volume: 16 | Issue: 1-2 | Page No.: 30-36
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Authors

Erna P. Setyowati

Umar Anggara Jenie

Sudarsono

L. Broto Kardono

Keywords

Research Article

Apoptosis Induction of Bioactive Substance Theonellapeptolide 1d and 1-(Tetrahydro-4-Hydroxy-5-(Hydroxymethyl)Furan-2-yl)-5-Methyl Pyrimidine-2,4(1H,3H)-Dione Isolated from Kaliapsis sp. Sponge Collection from West Bali National Park Indonesia

Erna P. Setyowati, Umar Anggara Jenie, Sudarsono and L. Broto Kardono
A study about cancer cell selectivity and apoptosis cell death had been conducted against 5M74 (theonellapeptolide 1d) and 1 (1-(tetrahydro-4-hydroxy-5-(hydroxymethyl)furan-2-yl)-5-methylpyrimidine-2,4 (1H,3H)-dione). The 5M74 and 1 were isolated from Kaliapsis sp., sponge from West Bali National Park Indonesia. Cell selectivity was observed using heLa cell, myeloma cell, Raji cell and T47D cell. Apoptosis cell was conducted against the most sensitive cell with both isolates. The result were the 1 isolate was the most cytotoxic against myeloma cell because it had the lowest IC50 value namely 0.18 μg mL–1 while 5M74 isolate had the lowest IC50 value against Raji cell (7.8 μg mL–1). The isolated cell death test result was the 1 isolate increased apoptosis against myeloma cell. Moreover, on 5M74 isolate also increased apoptosis against Raji cell.
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How to cite this article

Erna P. Setyowati, Umar Anggara Jenie, Sudarsono and L. Broto Kardono, 2016. Apoptosis Induction of Bioactive Substance Theonellapeptolide 1d and 1-(Tetrahydro-4-Hydroxy-5-(Hydroxymethyl)Furan-2-yl)-5-Methyl Pyrimidine-2,4(1H,3H)-Dione Isolated from Kaliapsis sp. Sponge Collection from West Bali National Park Indonesia. Journal of Biological Sciences, 16: 30-36.

DOI: 10.3923/jbs.2016.30.36

URL: https://scialert.net/abstract/?doi=jbs.2016.30.36

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