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Journal of Biological Sciences

Year: 2016 | Volume: 16 | Issue: 6 | Page No.: 229-235
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Authors

Sawsan A. Rahimulddin

Ayat B. Al-Ghafari

Ulfat M. Omar

Huda A. Al Doghaither

Shiekhah M. Al Zahrani

Keywords

Background: The extracellular pH (pHex) of malignant tumors is acidic whereas, the pHex of tissues is more alkaline. Hence, slight changes in pHex may have an effect on the phenotype of cells. Objective: The aim of the current study is to illustrate the influence of pH and sterilization conditions of Zamzam Water (ZW) on the cell viability of human breast adenocarcinoma cell line (MCF-7) and human colon cancer cell line (HCT-116). Materials and Methods: The cell viability of cancer cells was determined using MTT assay after the treatment with ZW under different preparation conditions. Results: The results of this study revealed that ZW has a selective inhibitory effect on cancer cells. Only the natural non-adjusted pH (alkaline) ZW treatment reduces the growth of both MCF-7 (p≤0.00001) and HCT-116 cells (p≤0.0001). Conclusion: The selective cytotoxic effects of different ZW treatments on cancer cells are influenced by the pH value and sterilization conditions. Therefore, it is suggested that the high alkaline pH value and the presence of certain elements in ZW play a role in inhibiting the growth of cancer cells.
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How to cite this article

Sawsan A. Rahimulddin, Ayat B. Al-Ghafari, Ulfat M. Omar, Huda A. Al Doghaither and Shiekhah M. Al Zahrani, 2016. Influence of pH and Sterilization Conditions on the Inhibitory Effects of Zamzam Water on the Cell Viability of Cancer Cells. Journal of Biological Sciences, 16: 229-235.

DOI: 10.3923/jbs.2016.229.235

URL: https://scialert.net/abstract/?doi=jbs.2016.229.235

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