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Journal of Biological Sciences

Year: 2016 | Volume: 16 | Issue: 4 | Page No.: 136-140
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Authors

Ibrahim Dan Dano

Odile Ouwe Missi Oukem-Boyer

Ali Elhadji Mahamane

Hassimi Sadou

Keywords

Background: To analyze whether the determination of interleukin-6 levels in cerebrospinal fluid is useful as a biomarker for the severity of bacterial meningitis. Methodology: Cerebrospinal fluid was obtained from 120 patients aged 0-15 years with meningitis. They were classified as having bacterial meningitis (n = 85) or aseptic meningitis (n = 35) according to the cerebrospinal fluid white blood cell count, microbiological culture and molecular methods. Interleukin-6 levels were determined by enzyme-linked immunosorbent assay. Results: No significant change in the mean interleukin-6 level on the basis of clinical signs was observed in patients with bacterial meningitis. However, the cerebrospinal fluid total protein level was elevated in patients with alertness problems (3.41±2.26 g L–1). There was a significant correlation (Pearson correlation p≤0.05) between the cerebrospinal fluid glucose and total protein levels in patients with bacterial meningitis. The mean cerebrospinal fluid interleukin-6 level (4,472.0±2,494.52 pg mL–1) in patients with bacterial meningitis whose disease outcome was fatal was significantly higher (p≤0.05) than that of those who survived the disease (2,983.28±2,612.13 pg mL–1). Conclusion: Interleukin-6 is a potential biomarker for identifying bacterial meningitis patients with a high risk of death who require intensive care.
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How to cite this article

Ibrahim Dan Dano, Odile Ouwe Missi Oukem-Boyer, Ali Elhadji Mahamane and Hassimi Sadou, 2016. Determination of Interleukin-6 (IL-6) in Cerebrospinal Fluid: Potential Role for the Evaluation of the Vital Prognosis in Bacterial Meningitis. Journal of Biological Sciences, 16: 136-140.

DOI: 10.3923/jbs.2016.136.140

URL: https://scialert.net/abstract/?doi=jbs.2016.136.140

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