Preventive and Curative Potential of Vigna mungo against Metabolic Syndrome in Acute and Chronic Rat Models

Research Article

**Preventive and Curative Potential of Vigna mungo against Metabolic Syndrome in Acute and Chronic Rat Models**

Ginpreet Kaur, Rachana Somaiya and Sameer Patel

The modern lifestyle of high intake of high-calorie food associated with reduced energy expenditure plays an important role on the increased prevalence of type 2 diabetes. There is a multiplicity of effective treatment choices with synthetic drugs, but they have a number of side effects. Vigna mungo (Black gram), while acting as one of the richest sources of proteins and amino acids, has high fiber content which could enhance the lipoprotein lipase activity. The present study evaluates the antihyperlipidemic and antihyperglycemic potential of V. mungo in triton and high-fat diet in combination with low dose streptozotocin (HFD+STZ) rat models. Orally administered V. mungo extract (VME) at a dose 100 mg kg^–1 in both acute and chronic rat models significantly lowered levels of triglycerides, LDL and total cholesterol and significantly increased HDL levels in comparison to triton and HFD+STZ induced rats. Glucose level analysis on the blood plasma level suggested that VME at 100 mg kg^–1 shows significant reduction of 34.90% in glucose level on HFD+STZ induced rats. The determination of Oral Glucose Tolerance Test (OGTT) showed that VME at 100 mg kg^–1, shows significant improvement in glucose tolerance to exogenously administered glucose (2 g kg^–1). The results observed for biochemical analysis, blood glucose level and OGTT support the medicinal value of V. mungo as a potential source having antihyperlipidemic and antihyperglycemic properties for the prevention and treatment of type 2 diabetes.

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Ginpreet Kaur, Rachana Somaiya and Sameer Patel, 2015. Preventive and Curative Potential of Vigna mungo against Metabolic Syndrome in Acute and Chronic Rat Models. Journal of Biological Sciences, 15: 85-91.

DOI: 10.3923/jbs.2015.85.91

URL: https://scialert.net/abstract/?doi=jbs.2015.85.91

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Authors

Ginpreet Kaur

Rachana Somaiya

Sameer Patel

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Research Article

**Preventive and Curative Potential of Vigna mungo against Metabolic Syndrome in Acute and Chronic Rat Models**

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