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Journal of Biological Sciences

Year: 2015 | Volume: 15 | Issue: 1 | Page No.: 50-55
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Authors

Prawej Ansari

Shofiul Azam

J.M.A. Hannan

Shah Mohammed Shafi

Ismail Hussein Ahmed

Sharmin Rahman

Keywords

We aimed to investigate and evaluate the anti-inflammatory and analgesic effectiveness of common tree in the locality of Bangladesh, Lophopetalum javanicum. Our study includes; the investigation of the phytochemical composition and in-vivo analgesic and anti-inflammatory activity of Methanolic Extract of Lophopetalum javanicum (MELJ). On that point are four methods we applied to investigate the effect, including; Formalin induced paw edema and Carrageenan induced paw edema for anti-inflammatory assay and to access analgesic effect we used the Hot plate method and Tail immersion method. At the dose of 500 mg kg–1 the extract shows the considerable inhibitory effect on paw increase 1 h after carrageenan administration, by inhibiting over 50%. The maximum inhibition (52.27±0.017%; p<0.0001) elicited by the methanolic extract at 3 h after carrageenan injection. In the assay of hotplate method, L. javanicum increases pain tolerance, time up to 17.83±0.085 min, where the compared standard lengthened response time to 21.68±0.427 min. In tail immersion method the response time was elongated at 600 mg kg–1 by L. javanicum 4.49±0.214 (p<0.0001) after 2 h of extract induction. This study reflects that the plant is effective in inhibiting pain mediators, thus can be developed as analgesic and anti-inflammatory agent through proper isolation and adjustment.
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How to cite this article

Prawej Ansari, Shofiul Azam, J.M.A. Hannan, Shah Mohammed Shafi, Ismail Hussein Ahmed and Sharmin Rahman, 2015. Investigation of Anti-inflammatory and Analgesic Properties of Methanolic Extract of Lophopetalum javanicum Leaves. Journal of Biological Sciences, 15: 50-55.

DOI: 10.3923/jbs.2015.50.55

URL: https://scialert.net/abstract/?doi=jbs.2015.50.55

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