Thyroid and liver are among two vital and important organs which are interrelated
in health and disease. The cooperation of thyroid and liver is extremely vital
for a proper functional behavior for both thyroid and liver. Liver crucial role
in the basic metabolic rate, growth and development is due to the liver ability
to transfer the thyroid hormone and deliver it to the various organs intracellular
due to thyroid hormone transporting system which is mediated by the liver. Thyrotoxicosis
defined as the clinical manifestation of hyperthyroidism, a symptom with various
adverse effects on the liver, heart, vascular, nervous and gastrointestinal systems.
There are many reports demonstrating the negative side effect of hyperthyroidism
on liver function tests which occur due to the accompanying clinical manifestation
of thyrotoxicosis. In severe form of hyperthyroidism in addition to liver biochemical
alteration and elevated liver enzymes, damages to hepatocytes will occur. Therefore
it is strongly recommended that subjects with either of hyperthyroid or liver
dysfunction should be carefully examined simultaneously for both organs to have
a clear cut diagnosis and to assist the patient with proper therapeutically treatments.