Enzymatic in vitro Anti-diabetic Activity of Few Traditional Indian Medicinal Plants

Research Article

**Enzymatic in vitro Anti-diabetic Activity of Few Traditional Indian Medicinal Plants**

Pardeep Kumar, Meenu Mehta, Saurabh Satija and Munish Garg

Controlling post-prandial hyperglycaemia through enzymatic inhibition of starch degradation is an effective therapeutic approach in the management of diabetes mellitus. To achieve this, twelve indigenous antidiabetic Indian medicinal plants such as Trigonella foenum-graecum, Ocimum sanctum, Aegle marmelos, Plantago ovata, Catharanthus roseus, Alium cepa, Azadirachta indica, Aloe vera, Magnifera indica, Terminalia chebula, Eugenia jambolana and Linum usitatisumum were subjected to sequential solvent extraction and thereafter, 48 fractions were screened for their α-amylase inhibitory potential at three dosage levels in vitro. Out of the 144 samples, Eugenia jambolana water extract showed maximum α-amylase inhibitory activity with IC₅₀value 1.33 mg mL^-1 in comparison with standard drug acarbose (IC₅₀ value 0.86 mg mL^-1). Quantitative phytochemical analysis of the lead extract revealed the presence of phenolic content as 69.68 mg tannic acid equivalent g^-1 while flavonoidal content as 57.39 mg rutin equivalent g^-1. Present study indicated Eugenia jambolana as a potential α-amylase inhibitor in the management of diabetes.

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Pardeep Kumar, Meenu Mehta, Saurabh Satija and Munish Garg, 2013. Enzymatic in vitro Anti-diabetic Activity of Few Traditional Indian Medicinal Plants. Journal of Biological Sciences, 13: 540-544.

DOI: 10.3923/jbs.2013.540.544

URL: https://scialert.net/abstract/?doi=jbs.2013.540.544

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Authors

Pardeep Kumar

Meenu Mehta

Saurabh Satija

Munish Garg

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Research Article

**Enzymatic in vitro Anti-diabetic Activity of Few Traditional Indian Medicinal Plants**

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