Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Biological Sciences
  Year: 2013 | Volume: 13 | Issue: 5 | Page No.: 412-416
DOI: 10.3923/jbs.2013.412.416
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Acetylcholinesterase Inhibition and Antioxidant Activity of Syzygium cumini, S. aromaticum and S. polyanthum from Indonesia

Latifah K. Darusman, Wulan Tri Wahyuni and Farahdina Alwi

Abstract:
Acetylcholinesterase inhibition and antioxidant activity are considered to be highly correlated with Alzheimer’s disease treatment. Plants from Syzygium genus reported as potential antioxidant, however the potency of plants as acetylcholinesterase inhibitor has not been properly investigated. The present study was design to investigate the antioxidant and acetylcholinesterase inhibitory activity of three Syzygium plants, Syzygium cumini, S. aromaticum and S. polyanthum. Leaves of S. cumini, S. aromaticum, S. polyanthum and bud of S. aromaticum extracted with gradient polarity solvent consist of n-hexane, ethyl acetate and methanol. Acetylcholinesterase inhibitory activity was measured with modified Ellman method at 412 nm and physostigmine was used as positive control, meanwhile antioxidant activity measured based on 1,1-diphenyl-2-picrylhydrazil free radical scavenging test. The methanol extract of S. aromaticum leaves, S. aromaticum bud, S. polyanthum leaves and the ethyl acetate extract of S. polyanthum leaves were potential as acetylcholinesterase inhibitors. The IC50 values of the extracts respectively were 42.10±1.41; 45.25±0.07; 47.30±3.54 and 45.10±8.06 μg mL-1 when IC50 value of physostigmine was 0.01±0.002 μg mL-1. Meanwhile, antioxidant activity of potential extracts successively were 11.43±0.88, 9.26±0.25, 21.24±1.14 and 13.70±0.24 μg mL-1.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Latifah K. Darusman, Wulan Tri Wahyuni and Farahdina Alwi, 2013. Acetylcholinesterase Inhibition and Antioxidant Activity of Syzygium cumini, S. aromaticum and S. polyanthum from Indonesia. Journal of Biological Sciences, 13: 412-416.

DOI: 10.3923/jbs.2013.412.416

URL: https://scialert.net/abstract/?doi=jbs.2013.412.416

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 

Curve Bottom