Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Biological Sciences
  Year: 2013 | Volume: 13 | Issue: 4 | Page No.: 271-276
DOI: 10.3923/jbs.2013.271.276
Berberine Disturbs the Expression of Sex-hormone Regulated Genes in β-naphthoflavone-induced Mice
Thinnakorn Lao-Ong, Waranya Chatuphonprasert and Kanokwan Jarukamjorn

Abstract:
Berberine is a major active constituent in several medicinal plants such as Coscinium fenestratum, Berberis aristata, Coptis japonica and Coptis chinensis. Berberine possesses a wide range of biochemical and pharmacological activities including anti-inflammation, anti-microorganism, anti-cancer activities and anti-diabetes. In this study, we determined the effect of berberine, in combination with β-naphthoflavone (BNF, a pro-carcinogen), on the expression of sex-hormone synthesis genes at mRNA level including CYP17, CYP19, 3β-HSD, 17β-HSD1, 17β-HSD3 in mouse testes. The single treatment of berberine up-regulated the expression of testicular CYP17, 3β-HSD and 17β-HSD1 mRNA. BNF up-regulated only 17β-HSD1 mRNA. Moreover, the combination of berberine and BNF up-regulated the expression of CYP17 and 3β-HSD. These observations suggested that berberine might disturb sex-hormone synthesis pathway; consequently possibly resulted in modification of estrogen or testosterone synthesis. Therefore, a caution should be noted for the use of berberine as an alternative medicine, especially at high dose or long period.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
How to cite this article:

Thinnakorn Lao-Ong, Waranya Chatuphonprasert and Kanokwan Jarukamjorn, 2013. Berberine Disturbs the Expression of Sex-hormone Regulated Genes in β-naphthoflavone-induced Mice. Journal of Biological Sciences, 13: 271-276.

DOI: 10.3923/jbs.2013.271.276

URL: https://scialert.net/abstract/?doi=jbs.2013.271.276

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 

Curve Bottom