Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Biological Sciences
  Year: 2012 | Volume: 12 | Issue: 7 | Page No.: 421-425
DOI: 10.3923/jbs.2012.421.425
Short-term Feeding Effects of Origanum syriacum Crude Extract on Immobilization Stress Induced Antioxidant Defense Changes in Rat
Moyad Shahwan, Tariq Al-Qirim and Ammar Bader

Abstract:
Ethnomedically genus Origanum L. is commonly used in many countries due to its stimulating, analgesic, antitussive, expectorant, sedative, anti-inflammatory and antihelminthic agent. The aim of this research was to study the antioxidant potential of the aerial parts of origanum syriacum extract and to evaluate its effect on the modulation of restraint induced oxidative stress. Rats were treated with crude extract of origanum syriacum alone and both before (pre-extract stress treated) and after (post-extract stress treated) 6 h of stress exposure. Pro-oxidant effect of rat plasma was evaluated by determining the activities of Superoxide Dismutase (SOD), Catalase (CAT), Glutathione-S-Transferase (GST) and the levels of glucose, uric acid and lipid peroxidation (MDA). About 6 h of restraint stress caused a significant decrease in the activities of SOD, CAT and GST and the level of glucose, while increase in the levels of MDA and uric acid. The post treatment of crude extract was found more effective in restoring restraint stress induced changes in rat plasma than pre treatment. In order to reduce oxidative stress, observed in many pathological conditions, the O. syriacum extract can be given both as a prophylactic and therapeutic supplement for scavenging free radicals.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    Hypoglycemic Effect, Biochemical and Histological Changes of Spondias mombin Linn. and Parinari polyandra Benth. Seeds Ethanolic Extracts in Alloxan-induced Diabetic Rats
How to cite this article:

Moyad Shahwan, Tariq Al-Qirim and Ammar Bader, 2012. Short-term Feeding Effects of Origanum syriacum Crude Extract on Immobilization Stress Induced Antioxidant Defense Changes in Rat. Journal of Biological Sciences, 12: 421-425.

DOI: 10.3923/jbs.2012.421.425

URL: https://scialert.net/abstract/?doi=jbs.2012.421.425

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 

Curve Bottom