Rosmarinic Acid Prevents the Oxidation of Low Density Lipoprotein (LDL) In vitro


	Journal of Biological Sciences
	Year: 2012 \| Volume: 12 \| Issue: 5 \| Page No.: 301-307 DOI: 10.3923/jbs.2012.301.307

Rosmarinic Acid Prevents the Oxidation of Low Density Lipoprotein (LDL) In vitro

Hassan Ahmadvand, Ali Khosrobeigi, Leila Nemati, Maryam Boshtam, Narges Jafari, Reza Haji Hosseini, Yadollah Pournia, Hassan Ahmadvand, Ali Khosrobeigi, Leila Nemati, Maryam Boshtam, Narges Jafari, Reza Haji Hosseini and Yadollah Pournia

Abstract: The objective of the present study was to assess various antioxidative activities of Rosmarinic Acid (RA) and its effect on oxidation of Low Density Lipoprotein (LDL) induced by CuSO₄ in vitro. It was demonstrated that RA was able to inhibit LDL oxidation and decrease the resistance of LDL against oxidation. Rosmarinic acid showed a decrease the formation of malondialdehyde (MDA) rate of 31.8, 36.7 and 50.3% at concentrations ranging from 100- 400 μM, respectively, against oxidation in vitro. The inhibitory effects of the RA on LDL oxidation were dose-dependent. Total antioxidant capacity of RA was 0.65±0.03 mmol of ascorbic acid equivalents/mmol RA. The RA showed remarkable scavenging activity on 2,2-diphenyl-picrylhydrazyl (DPPH) (IC₅₀ 0.06±0.004 μM). This study showed that RA is a potent antioxidant and prevents the oxidation of LDL in vitro and it may be suitable for use in food and pharmaceutical applications.

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How to cite this article:

Hassan Ahmadvand, Ali Khosrobeigi, Leila Nemati, Maryam Boshtam, Narges Jafari, Reza Haji Hosseini, Yadollah Pournia, Hassan Ahmadvand, Ali Khosrobeigi, Leila Nemati, Maryam Boshtam, Narges Jafari, Reza Haji Hosseini and Yadollah Pournia, 2012. Rosmarinic Acid Prevents the Oxidation of Low Density Lipoprotein (LDL) In vitro. Journal of Biological Sciences, 12: 301-307.

DOI: 10.3923/jbs.2012.301.307

URL: https://scialert.net/abstract/?doi=jbs.2012.301.307

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