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Journal of Biological Sciences
  Year: 2012 | Volume: 12 | Issue: 5 | Page No.: 272-279
DOI: 10.3923/jbs.2012.272.279
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Assessment of Kidney Injuries and Other Diseases in Juvenile Diabetes
Hawazen Al-Amri, Sahira Lary and Taha Kumosani

The increasing reports of Insulin Dependent Diabetes Mellitus (IDDM) among the children of Saudi Arabia are of due scientific concern. Random mid-day urine samples were obtained from 30 diabetic patients (15 males, 15 females) and 50 subjects (25 males, 25 females) not under medication and without clinical evidence of renal disease or diabetes mellitus were used as controls. Two urinary enzymes, N-acetyl-beta-D-glucosaminidase (NAG) and Alanine Aminopeptidase (AAP) were measured in the urine, together with microalbuminuria, total protein and Creatinine (Cr) concentrations. In diabetic patients, NAG, Microalbuminuria (MAU) and Total Protein (TP) were found to be elevated which indicated that these children were prone to kidney damage in the future. However, as these diabetic children had not yet developed any clinically measurable kidney damage, therefore other parameters such as, Alkaline Phosphatase (AP), AAP and urinary creatinine were not elevated. This elevation in the enzyme-levels was most probably due to dysfunction of their kidneys. Urinary NAG assay therefore could be used as an alternative measurement of renal dysfunction. The assay coupled to the logistic regression equation described herein, is expected to be a useful clinical tool for predicting incipient nephropathy in adults and children. A routine check-up focused on the markers mentioned in this study might help the patients in practicing caution to avoid any future health threat posed by diabetes and associated kidney damage.
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How to cite this article:

Hawazen Al-Amri, Sahira Lary and Taha Kumosani, 2012. Assessment of Kidney Injuries and Other Diseases in Juvenile Diabetes. Journal of Biological Sciences, 12: 272-279.

DOI: 10.3923/jbs.2012.272.279








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