Dose-related Influence of Esculetin (6,7-dihydroxy-coumarin) on Some Liver and Prostate Function Markers of Male Wistar Rats


	Journal of Biological Sciences
	Year: 2012 \| Volume: 12 \| Issue: 4 \| Page No.: 253-257 DOI: 10.3923/jbs.2012.253.257

Dose-related Influence of Esculetin (6,7-dihydroxy-coumarin) on Some Liver and Prostate Function Markers of Male Wistar Rats

A.C.C. Egbuonu, A.E. Ogbu and L.U.S. Ezeanyika

Abstract: The study aimed to ascertain the effect of esculetin (Esc) on some liver and prostate function markers of male Wistar rats. Thirty male Wistar rats were divided into five groups (n = 6). Groups A, B and C were administered with 6.0, 12.0 and 24.0 mg kg^-1 b.wt. of esculetin, respectively. Groups D and E were administered with 0.2 mL of the vehicle control (10% Dimethyl Sulfoxide (DMSO)) and 0.2 mL of the normal control (distilled water (DW)), respectively. Administration was per oral after every 24 h for 28 days. On comparison with the controls, serum enzymes; aspartate aminotransferase (AST), alanine aminotransferase (ALT) and Alkaline Phosphatase (ALP), activities of the esculetin-fed rats decreased in a dose dependent manner. The decrease was significant (p<0.05) except that of ALP activity (79.12±11.82 IU L^-1) that was not significant (p>0.05) at the 6.0 mg kg^-1 dose level. Esculetin exposure in the rats induced a dose dependent decrease in Total Acid Phosphatase (TACP) and Prostatic Acid Phosphatase (PACP) activities of the rats serum. However, the decrease was not significant (p>0.05) except that of PACP activity (0.76±0.28 IU L^-1) that decreased sgnificantly (p<0.05) in the group treated with 24 mg kg^-1 b.wt. of esculetin. The results of this study suggest that esculetin caused a dose dependent improvement of these markers. Thus, repeated exposure to esculetin may not impair the functional capacity of the associated organs, particularly the liver and prostate, of the male rats, irrespective of dose.

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How to cite this article:

A.C.C. Egbuonu, A.E. Ogbu and L.U.S. Ezeanyika, 2012. Dose-related Influence of Esculetin (6,7-dihydroxy-coumarin) on Some Liver and Prostate Function Markers of Male Wistar Rats. Journal of Biological Sciences, 12: 253-257.

DOI: 10.3923/jbs.2012.253.257

URL: https://scialert.net/abstract/?doi=jbs.2012.253.257

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