Cerebroprotective Effect of Date Seed Extract (Phoenix dactylifera) on Focal Cerebral Ischemia in Male Rats


	Journal of Biological Sciences
	Year: 2012 \| Volume: 12 \| Issue: 3 \| Page No.: 180-185 DOI: 10.3923/jbs.2012.180.185

Cerebroprotective Effect of Date Seed Extract (Phoenix dactylifera) on Focal Cerebral Ischemia in Male Rats

T.P. Kalantaripour, M. Asadi-Shekaari, M. Basiri and A. Gholaamhosseinian Najar

Abstract: In the present study, we investigate the role of Date Seed Extract (DSE) in protection against cerebral ischemic damages. Focal cerebral ischemia was induced by using Middle Cerebral Artery Occlusion (MCAO) method in male rats. DSE was administrated at the dose of 80 mg kg^-1 i.p. 30 min after MCAO. Superoxide Dismutase (SOD), Malondialdehyde (MDA) and Total antioxidant Activity (TAS) were measured. Morphological studies and behavioral activity were also done. MCAO significantly decreased SOD and TAS activities. MDA content significantly was elevated by MCAO. Motor coordination was also decreased due to transient ischemia. Treatment with DSE attenuated all of alterations and neuronal damage induced by MCAO in male rats. The data showed that treatment with DSE could protect cortical neurons against cerebral-induced injuries most probably due to its antioxidant properties.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Neuroprotection in Acute Ischemia and Ischemia/Reperfusion in Rat Retina

•	Cerebroprotective Effect of Root Extract of Asparagus racemosus Willd. in Global Cerebral Ischemia in Rats

•	The Neuroprotective Potentials of Sour (Hibiscus sabdariffa,Calyx) and Green (Camellia sinensis) Teas on Some Pro-Oxidants Induced Oxidative Stress in Brain

•	Neuroprotetive Effect of Curcuma longa Alcoholic Extract on Peripheral Nerves Degeneration after Sciatic Nerve Compression in Rats

How to cite this article:

T.P. Kalantaripour, M. Asadi-Shekaari, M. Basiri and A. Gholaamhosseinian Najar, 2012. Cerebroprotective Effect of Date Seed Extract (Phoenix dactylifera) on Focal Cerebral Ischemia in Male Rats. Journal of Biological Sciences, 12: 180-185.

DOI: 10.3923/jbs.2012.180.185

URL: https://scialert.net/abstract/?doi=jbs.2012.180.185

COMMENT ON THIS PAPER

	Full Name:
	E-mail:
	Comments:

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		AGRICOLA
		AGRIS
		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		EMBASE
		Google Scholar
		SCIMAGO