Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Biological Sciences
  Year: 2012 | Volume: 12 | Issue: 3 | Page No.: 128-137
DOI: 10.3923/jbs.2012.128.137
Low Doses of Gamma Radiation may Impair Testicular Tissue in a Rat Treated CCl4 Model: Role of BM Transplantation
N. Hanafi

Abstract: Treatment of carbon tetrachloride (CCl4) 1 mL kg-1 in olive oil (1:1) twice a week for 8 weeks to albino male rat caused a significant increase in serum level of alanine transaminase (ALT) and aspartate transaminase (AST). Injury to liver, resulting in loss of its normal physiological/biochemical functions, may adversely affect a secondary organ like testis. In the current study young adult rats were treated by Carbon tetrachloride (CCl4) two times per week and/or continuously whole body γ-irradiated (R) at a dose level 0.5 Gy, two times per week for 8 weeks. The previous groups were treated by bone marrow transplantation (BMT). Plasma estradiol and testosterone concentrations in animals sera were analyzed. Histopathological, apoptosis and necrosis examinations were done in testicular tissues. Either CCl4 or R exposure alone or combined reflect testicular seminiferous tubules atrophy, peritubular fibrosis and apoptotic cells in seminiferous epithelium and Leydig cells. BMT reflect some recurrence of normal structure in testis tissue of CCl4 group. Meanwhile R and CCl4 R groups showed atrophied testicular seminiferous tubules, great interstitial hyperplasia, deposition of collagen fibres around blood vessels and presence of interstitial apoptotic and necrotic tissue cells. CCl4 treatment recorded anon significant change in plasma testosterone and a significant decrease in estradiol concentration. γ-irradiation either alone or combined with CCl4 treatments recorded a significant reduction in testosterone level and significant increase in estradiol concentration. BMT recorded a significant increase in testosterone level and anon significant change in estradiol level following CCl4 or irradiation either alone or combined. In conclusion low doses of γ- radiation impair testicular tissue in a rat treated CCl4 model. BM transplantation recorded increase in this testicular damage.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Testicular Histopathological Alterations in Rats Treated with Sumithion® NP 25/2.5 EC, Insecticide
  •    Hepatoprotective Effects of Camel Milk against CCl4-induced Hepatotoxicity in Rats
  •    Reduction of Carbon Tetrachloride-Induced Rat Liver Injury by Coffee and Green Tea
How to cite this article:

N. Hanafi , 2012. Low Doses of Gamma Radiation may Impair Testicular Tissue in a Rat Treated CCl4 Model: Role of BM Transplantation. Journal of Biological Sciences, 12: 128-137.

DOI: 10.3923/jbs.2012.128.137

URL: https://scialert.net/abstract/?doi=jbs.2012.128.137
 
COMMENT ON THIS PAPER
 
 
 

 
  Navigation
 
  Online First
  Current Issue
  Previous Issues
  Editorial Board
  Submit a Manuscript
  Guide to Authors
  Subscribe to E-alerts

  Indexed In
 
  AGRICOLA
  AGRIS
  ASCI-Database
  Asian Digital Library
  Cambridge Scientific Abstract
  EMBASE
  Google Scholar
  SCIMAGO

       

       

Science Alert
Curve Bottom