Submit Manuscript

Journal of Biological Sciences

Year: 2011 | Volume: 11 | Issue: 8 | Page No.: 475-480
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 830

Search

Authors

I. Batubara

L.K. Darusman

T. Mitsunaga

H. Aoki

M. Rahminiwati

E Djauhari

K. Yamauchi

Keywords

This study aims to obtain active compounds from Intsia palembanica with skin whitening activity. I. palembanica methanol extracts were separated using chromatography techniques and yielded 3 flavanols. Isolated compounds along with 6 other flavonoid compounds were analyzed for tyrosinase inhibitory activity and inhibition of melanin cell growth in B16 cell. The results showed that (-)-robidanol is the most potent tyrosinase inhibitor (IC50 monophenolase 8.7 μM; diphenolase 26.6 μM) and inhibit melanin synthesis 46.2% compared to control (at 100 μM). In conclusion, (-)-robidanol is the best compound as a whitening agent.
PDF Fulltext XML References Citation

Related Articles

Tyrosinase Kinetic Inhibition of Active Compounds from Intsia palembanica
Growth Increments of Indigenous Species Planted in Secondary Forest Area
Potency of Indonesian Medicinal Plants as Tyrosinase Inhibitor and Antioxidant Agent
Chemically Induced Pigmentary Changes of Human Skin, Interaction of Some Azo Dyes with Human DNA
Growth Performance of 9-Years-Old selected 5 Indigenous Wood Species Planted on Degraded Forest Land
Down-Regulation of Tyrosinase, TRP-2 and MITF Expressions by Neolitsea aciculata Extract in Murine B16 F10 Melanoma

Leave a Comment

Your email address will not be published. Required fields are marked *