Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Biological Sciences
  Year: 2011 | Volume: 11 | Issue: 7 | Page No.: 433-441
DOI: 10.3923/jbs.2011.433.441
Synergic Interactions Between Selected Botanical Extracts and Tetracycline Against Gram Positive and Gram Negative Bacteria
W.A. Hussin and W.M. El-Sayed

Abstract:
The potential use of plants as antimicrobial agents in medicine has not been fully exploited. The present study was carried out to investigate the synergic interaction of dichloromethane/methanol extracts from Punica granatum (PG), Thymus vulgaris (TV), Commiphora molmol (CM) and Achillea fragrantissima (AF) with tetracycline against Gram positive (Staphylococcus aureus ATCC 25923 and Bacillus megaterium ATCC 14591) and Gram negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Klebsiella pneumonia ATCC 700603) bacterial strains. All extracts had a significant antibacterial activity against all tested bacteria within concentrations range of (0.1-50 mg/disk). The lowest Minimum Inhibitory Concentration (MIC) recorded was 1 mg mL-1. The recorded MICs values of PG and TV against Gram negative bacteria were higher than those against Gram positive strains. Combination of PG, TV, or CM with tetracycline achieved synergetic interaction against tested bacteria as indicated from fractional inhibitory concentration and confirmed by time kill assays. CM, PG and TV significantly increased the Post Antibiotic Effect (PAE) of tetracycline from 1 h to 3, 4 and 5 h, respectively. The results suggested the use of these plants in extending the lifetime of fading antibiotics.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    Redox Potential of Pomegranate (Punica granatum) and Boldo (Peumus boldus) Included in the Diets of New Zealand White Rabbits
  •    Pharmacology and Phytochemistry of Pakistani Herbs and Herbal Drugs Used for Treatment of Diabetes
  •    Plant as a Source of Natural Antiviral Agents
How to cite this article:

W.A. Hussin and W.M. El-Sayed, 2011. Synergic Interactions Between Selected Botanical Extracts and Tetracycline Against Gram Positive and Gram Negative Bacteria. Journal of Biological Sciences, 11: 433-441.

DOI: 10.3923/jbs.2011.433.441

URL: https://scialert.net/abstract/?doi=jbs.2011.433.441

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 

Curve Bottom