Endogenous and Exogenous Approaches Towards Kidney Regeneration: A Review


	Journal of Biological Sciences
	Year: 2010 \| Volume: 10 \| Issue: 8 \| Page No.: 705-717 DOI: 10.3923/jbs.2010.705.717

Endogenous and Exogenous Approaches Towards Kidney Regeneration: A Review

Rajni Chhetri, T.V. Meenambigai and Veerasamy Sejian

Abstract: This review focused on our current understanding of the renal adult stem cells and their participation in kidney repair and regeneration. Currently, cells (growing in vitro) are being used as a replacement therapy/regenerative medicine with the great potential to treat kidney failure or other degenerative diseases. Regenerative medicine is now considered of great hope not only to control but also to cure some of the diseases which is otherwise difficult to treat. Recent studies have indicated that adult stem cells, either in the kidney itself or derived from the bone marrow, could participate in this repair process and might therefore be utilized clinically to treat acute renal failure. After renal ischemic injury, there is a upregulation of stromal cell-derived factor-1 expresson found in the kidney, which can induce leukocytosis and kidney repair. Renal stem cells, both from the renal papilla or the CD24+CD133+ cell niche of the Bowman’s capsule could differentiate into adult epithelial cells or tubular cells such as podocytes participate in this renal repair. Bone marrow-derived stem cells appeared to have a capacity for transdifferentiation and to be able to replace damaged renal tissue by replacing tubular epithelial cells, mesangial cells, endothelial cells and even podocytes. It is apparent from this review that there is a hidden potential within the kidney as well as in the bone marrow cells to stimulate endogenous or exogenous kidney regeneration. Further it can be speculated that harnessing the potential of these stem cells will go a long way in management and recovery of kidney failure through regenerative medicine approach.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Multipotent Differentiation Potential of Buffalo Adipose Tissue Derived Mesenchymal Stem Cells

•	Acute Effect of Cadmium Treatment on the Kidney of Rats: Biochemical and Ultrastructural Studies

•	Association Between Serum Biochemistry of Leghorn Chickens and Changes in Renal Tissues Induced by High Calcium and High Urea Diets

•	Renal Damage Mediated by Oxidative Stress in Mice Treated with Aluminium Chloride: Protective Effects of Taurine

•	Effects of Valproat and Clonazepam on Kidney Tissue of Female Rats

How to cite this article:

Rajni Chhetri, T.V. Meenambigai and Veerasamy Sejian, 2010. Endogenous and Exogenous Approaches Towards Kidney Regeneration: A Review. Journal of Biological Sciences, 10: 705-717.

DOI: 10.3923/jbs.2010.705.717

URL: https://scialert.net/abstract/?doi=jbs.2010.705.717

COMMENT ON THIS PAPER

	Full Name:
	E-mail:
	Comments:

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		AGRICOLA
		AGRIS
		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		EMBASE
		Google Scholar
		SCIMAGO

Follow @scialert

Science Alert