Subscribe Now Subscribe Today
Science Alert
Curve Top
Journal of Biological Sciences
  Year: 2010 | Volume: 10 | Issue: 3 | Page No.: 231-236
DOI: 10.3923/jbs.2010.231.236
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Effect of Citrus karna Peel Extract on Stress Induced Peptic Ulcer in Rat

S. Sood, A. Muthuraman, N.S. Gill, M. Bali and P.D. Sharma

The present study was designed to evaluate the antioxidant and anti-ulcerogenic potential of Citrus karna peel extract. Extraction of Citrus karna peels was carried out using different solvents. Phytochemical screening and evaluation of antioxidant activity of all the extracts were carried out. Further, anti-ulcerogenic activity of ethyl acetate extract of Citrus karna peels (EtCK) was assessed in water immersion (WIS) and hypothermic restraint (HRS) stress models at different doses (200, 300 and 400 mg kg-1). EtCK showed ulcer protective effect in both models in a dose dependent manner, which was indicated by decrease in the ulcerative index and thiobarbituric acid reactive species (TBARS) level in the blood and gastric tissue samples as compared to the disease control group. Moreover, antioxidant markers i.e., reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in the blood and tissue samples were found to be significantly increased in medium and high doses of EtCK (300 and 400 mg kg-1) treated groups similar to that of ranitidine treated group. The present study concluded that EtCK has a significant anti-ulcer effect at a dose level of 300 and 400 mg kg-1. Hence, it may be considered as a useful herbal therapeutic agent for the treatment of peptic ulcer disease.
PDF Fulltext XML References Citation Report Citation
  •    Evaluation of Antioxidant and Antiulcer Potentials of Prunus domestica Fruit Methanolic and Extract on Wistar Albino Rats
  •    Evaluation of Cassia tora Seeds for their Antioxidant and Antiulcer Activity
  •    Screening of Antioxidant and Antiulcer Potential of Citrullus colocynthis Methanolic Seed Extract
  •    Therapeutic Potential of Citrus medica L. Peel Extract in Carrageenan Induced Inflammatory Pain in Rat
How to cite this article:

S. Sood, A. Muthuraman, N.S. Gill, M. Bali and P.D. Sharma, 2010. Effect of Citrus karna Peel Extract on Stress Induced Peptic Ulcer in Rat. Journal of Biological Sciences, 10: 231-236.

DOI: 10.3923/jbs.2010.231.236






Curve Bottom