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| Evaluation of the Effects of Flunixin Meglumine, Ketoprofen and Phenylbutazone
Administration on the Brain, Renal and Hepatic Functions in Iranian Cross-Breed
Goats |
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R. Safarchi,
A.A. Mozaffari,
A. Derakhshanfar and O. Amiri Marvili |
Abstract:
Flunixin meglumine, ketoprofen and phenylbutazone were
classified with the group of compounds commonly referred to as Non-Steroidal
Anti-Inflammatory Drugs (NSAIDs). The purpose of this study was to evaluate
the brain, renal and hepatic effects of 3 NSAIDs (flunixin meglumine,
ketoprofen and phenylbutazone) when administered IV to clinically normal
Iranian cross-breed goats. The experiments were conducted on twenty clinically
normal adult male goats. Goats were randomly assigned to 4 groups: saline
(n = 5), flunixin meglumine (n = 5) ketoprofen (n = 5) and phenylbutazone
(n = 5). Drug administration was initiated at 8 AM on day 1 and continued
every 12 h for 12 days. Flunixin meglumine, ketoprofen and phenylbutazone
were administered at the dose rate of 2.2, 2.2 and 4.4 mg kg-1,
respectively. Daily blood and urine samples were collected from all goats
for hematology, enzyme activities and urinalysis. Immediately after euthanasia,
complete necropsy was performed on all goats and gross lesions were recorded.
Clinically, mild anorexia and diarrhea were observed during the study
only in phenylbutazone treated group. Mean total and differential of leukocytes,
RBC and PCV did not changed significantly. Serum biochemical analysis
indicated a significant treatment effect on urea nitrogen, creatinine
and enzyme activities. Treatment effect was not significantly evident
in results of urinalysis. Macroscopic and microscopic findings. Considering
brain, renal and hepatic lesions, the toxic potential of the NSAIDs, when
use of these compounds is contemplated in clinical cases, the risk of
adverse effects and the comparative toxic potential should be considered,
along with the efficacy of the compound for the condition being treated.
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How to cite this article:
R. Safarchi, A.A. Mozaffari, A. Derakhshanfar and O. Amiri Marvili, 2010. Evaluation of the Effects of Flunixin Meglumine, Ketoprofen and Phenylbutazone
Administration on the Brain, Renal and Hepatic Functions in Iranian Cross-Breed
Goats. Journal of Biological Sciences, 10: 170-173.
DOI: 10.3923/jbs.2010.170.173
URL: https://scialert.net/abstract/?doi=jbs.2010.170.173
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