Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Biological Sciences
  Year: 2010 | Volume: 10 | Issue: 2 | Page No.: 138-144
DOI: 10.3923/jbs.2010.138.144
Potency of Indonesian Medicinal Plants as Tyrosinase Inhibitor and Antioxidant Agent
I. Batubara, L.K. Darusman, T. Mitsunaga, M. Rahminiwati and E. Djauhari

Abstract:
The aim of this study is to screen whitening agent potency of 45 Indonesian plant materials from 35 species. All plant materials were extracted with methanol and 50% ethanol which resulted to 90 extracts. The methods for screening is based on tyrosinase inhibitor potency using mushroom tyrosinase and antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Scoring method was used to identify the best extract as whitening agent. Out of 90 extracts, merbau (Intsia palembanica) methanol and 50% ethanol extracts are the most potent extracts as tyrosinase inhibitor (for monophenolase and diphenolase). Their IC50 values are not significantly different with kojic acid as positive control. Based on antioxidant activity, merbau methanol extract (IC50: 3.87 μg mL-1) is the best antioxidant together with kayu putih (Melaleuca cajuputi) ethanol 50% extract (IC50: 5.76 μg mL-1) and Rhizopora sp. methanol extract (IC50: 5.90 μg mL-1). Their IC50 values are not significantly different with (+)-catechin (IC50: 2.94 μg mL-1) as positive control. In conclusion, merbau methanol extract is the most potent extract as whitening agent based on scoring data from its tyrosinase inhibitory and antioxidant activities.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Tyrosinase Kinetic Inhibition of Active Compounds from Intsia palembanica
  •    TNF-α Production Inhibitory Activity, Phenolic, Flavonoid and Tannin Contents of Selected Indonesian Medicinal Plants
  •    Flavonoid from Intsia palembanica as Skin Whitening Agent
  •    Indonesian Kepel Fruit (Stelechocarpus burahol) as Oral Deodorant
How to cite this article:

I. Batubara, L.K. Darusman, T. Mitsunaga, M. Rahminiwati and E. Djauhari, 2010. Potency of Indonesian Medicinal Plants as Tyrosinase Inhibitor and Antioxidant Agent. Journal of Biological Sciences, 10: 138-144.

DOI: 10.3923/jbs.2010.138.144

URL: https://scialert.net/abstract/?doi=jbs.2010.138.144

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom