Potency of Indonesian Medicinal Plants as Tyrosinase Inhibitor and Antioxidant Agent


	Journal of Biological Sciences
	Year: 2010 \| Volume: 10 \| Issue: 2 \| Page No.: 138-144 DOI: 10.3923/jbs.2010.138.144

Potency of Indonesian Medicinal Plants as Tyrosinase Inhibitor and Antioxidant Agent

I. Batubara, L.K. Darusman, T. Mitsunaga, M. Rahminiwati and E. Djauhari

Abstract: The aim of this study is to screen whitening agent potency of 45 Indonesian plant materials from 35 species. All plant materials were extracted with methanol and 50% ethanol which resulted to 90 extracts. The methods for screening is based on tyrosinase inhibitor potency using mushroom tyrosinase and antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Scoring method was used to identify the best extract as whitening agent. Out of 90 extracts, merbau (Intsia palembanica) methanol and 50% ethanol extracts are the most potent extracts as tyrosinase inhibitor (for monophenolase and diphenolase). Their IC₅₀ values are not significantly different with kojic acid as positive control. Based on antioxidant activity, merbau methanol extract (IC₅₀: 3.87 μg mL^-1) is the best antioxidant together with kayu putih (Melaleuca cajuputi) ethanol 50% extract (IC₅₀: 5.76 μg mL^-1) and Rhizopora sp. methanol extract (IC₅₀: 5.90 μg mL^-1). Their IC₅₀ values are not significantly different with (+)-catechin (IC₅₀: 2.94 μg mL^-1) as positive control. In conclusion, merbau methanol extract is the most potent extract as whitening agent based on scoring data from its tyrosinase inhibitory and antioxidant activities.

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How to cite this article:

I. Batubara, L.K. Darusman, T. Mitsunaga, M. Rahminiwati and E. Djauhari, 2010. Potency of Indonesian Medicinal Plants as Tyrosinase Inhibitor and Antioxidant Agent. Journal of Biological Sciences, 10: 138-144.

DOI: 10.3923/jbs.2010.138.144

URL: https://scialert.net/abstract/?doi=jbs.2010.138.144

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