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Journal of Biological Sciences
  Year: 2009 | Volume: 9 | Issue: 8 | Page No.: 889-893
DOI: 10.3923/jbs.2009.889.893
Neuroprotetive Effect of Curcuma longa Alcoholic Extract on Peripheral Nerves Degeneration after Sciatic Nerve Compression in Rats
M. Tehranipour and R. Javaheri

Abstract:
Wallerian degeneration in the CNS and PNS consists of degradation and phagocytosis of axons and their myelin sheath distal to the site of injury. The present study was undertaken to evaluate the possible antioxidant neuroprotective effect of Curcuma longa extract on neuronal death after sciatic nerve injury in rat. Treatment of Curcuma longa extract (100 mg kg-1, i.p.) at three different times (immediately, 3, 6 and 9 day after compression) significantly (p<0.05) reduced neuronal damage. The present study demonstrates that Curcuma longa extract treatment attenuates sciatic nerve injury and oxidative stress that’s following it. Because of antioxidative effect of Curcuma longa extract; treatment with this immediately or even delayed until 24 h may have the potential role to be used as a protective agent in neurodegenerative process.
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How to cite this article:

M. Tehranipour and R. Javaheri, 2009. Neuroprotetive Effect of Curcuma longa Alcoholic Extract on Peripheral Nerves Degeneration after Sciatic Nerve Compression in Rats. Journal of Biological Sciences, 9: 889-893.

DOI: 10.3923/jbs.2009.889.893

URL: https://scialert.net/abstract/?doi=jbs.2009.889.893

 
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