Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Biological Sciences
  Year: 2009 | Volume: 9 | Issue: 8 | Page No.: 884-888
DOI: 10.3923/jbs.2009.884.888
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Evaluating the Effect of Aquatic Extract of Cannabis sativa Seed on Spatial Memory Consolidation in Rats

M. Tehranipour and S. Ebrahimpour

Abstract:
As the point of physiology, memory form, from changes in the conducting message in the neural webs. These changes cause to formation of long-term potentiation. Δ9-THC is Psychotropic component 4-of Cannabis sativa plant; studies show this matter can bind cannabinoid receptor in CA1 area of hippocampus. Thus the aim of this study is evaluation the effect of aquatic extraction Cannabis sativa seed on spatial 7-memory consolidation in Rats. Forty male wistar Rats (3-4 mounth, 320-260 g) were completely divided into 4 experimental groups and control group. Cannabis sativa seed was extracted with Soxhlet apparatus. To test spatial memory, Morris water mazemaze (7 days, 4 trails) was used. Experimental groups with 50, 100, 150 and 210 mg kg-1 were injected in the peritoneal (IP) and after 1 h of injection spatial memory was scaled. The result show that experimental groups (50, 100 and 150 mg kg-1 doses), for learning time have significant level deduction in the comparison of control group (p<0.05), but experimental group with 18-210 mg kg-1 dose has not significant level in the comparison of control group (p<0.05). This LTP probably was done with Depolarization Induced Suppression of excitatory (DSE) mechanism in the CA1 area of Hippocampus that with neurotransmitter regulation cause to neuroplasticity.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Neuroendocrinological, Metabolic and Toxicological Effects of Chronic Cannabis Use among Male in Lagos
  •    Plant as a Source of Natural Antiviral Agents
How to cite this article:

M. Tehranipour and S. Ebrahimpour, 2009. Evaluating the Effect of Aquatic Extract of Cannabis sativa Seed on Spatial Memory Consolidation in Rats. Journal of Biological Sciences, 9: 884-888.

DOI: 10.3923/jbs.2009.884.888

URL: https://scialert.net/abstract/?doi=jbs.2009.884.888

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 

Curve Bottom