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Journal of Biological Sciences
  Year: 2009 | Volume: 9 | Issue: 6 | Page No.: 549-554
DOI: 10.3923/jbs.2009.549.554
The Clinical Utility of Vascular Endothelial Growth Factor as Predictive Marker for Systemic Lupus Erythematosus Activity in Children and Adolescents
Nevine S. ELhelaly, Ismail M. Elhawary, Iman A. Abd Alaziz, Mona I. Abd Alsalam, Hussien M. Elfishawy and Mai M. Sherif

Abstract:
This study conducted to investigate the serum concentration of Vascular Endothelial Growth Factor (VEGF) using an Enzyme-linked immunosorbent assay (ELISA) in a group of 23 children and adolescents with Systemic Lupus Erythematosus (SLE) and 25 healthy controls to asses for changes of VEGF in lupus patients and its relation to lupus activity. Vascular Endothelial Growth Factor (VEGF) was detectable in all patients with SLE and in all normal individuals. The level of serum VEGF in lupus patients was higher than control, also its level in active SLE was higher than inactive disease or in controls. We found that serum levels of VEGF was significantly higher in patients with renal involvement, patients with moderate to sever skin disease, neurological and joint involvement but the differences were statistically insignificant. A positive correlation was detected between higher VEGF serum levels and ESR and SLAM score (p<0. 01 and <0. 04, respectively). In conclusion, VEGF serum levels are higher in children and adolescents with SLE patients especially active lupus. Also, its level is correlated to many of clinical and laboratory parameter of lupus. So, it may be a useful marker of disease activity.
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How to cite this article:

Nevine S. ELhelaly, Ismail M. Elhawary, Iman A. Abd Alaziz, Mona I. Abd Alsalam, Hussien M. Elfishawy and Mai M. Sherif, 2009. The Clinical Utility of Vascular Endothelial Growth Factor as Predictive Marker for Systemic Lupus Erythematosus Activity in Children and Adolescents. Journal of Biological Sciences, 9: 549-554.

DOI: 10.3923/jbs.2009.549.554

URL: https://scialert.net/abstract/?doi=jbs.2009.549.554

 
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