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Journal of Biological Sciences
  Year: 2009 | Volume: 9 | Issue: 5 | Page No.: 509-513
DOI: 10.3923/jbs.2009.509.513
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Apoptotic Markers in Childhood Nephrotic Syndrome

Y.H. Kamel, H.M. Bazaraa, A.E. Elwan, N.A. Fahmy and O. Shaker

In order to investigate the status and role of serum MMP-9 and urinary annexin V in steroid resistant nephrotic syndrome, 60 children aged between 2 and 15 years were enrolled in this study. Serum MMP-9 and urinary annexin V excretion were measured N patients were examined for apoptotic bodies by DNA in situ. Serum MMP-9 was significantly higher in patients than controls (189.1± 150.6 and 87± 53.7 pg mL-1, respectively, p<0.0001). Urinary annexin V was also significantly higher (4.5± 0.3 compared to 2.7± 0.6 ng g-1 creatinine, p<0.0001). Apoptosis by DNA in situ was positive in 29 children (48%) and positive cases tend to have higher MMP-9 levels (p = 0.05). Those with focal segmental glomerulosclerosis had the highest apoptosis rates (69%) and the lowest response to CPA (29%). Responders had higher urinary annexin V (p = 0.03) and biopsy evidence of apoptosis (p = 0.003) than non-responders. Negative apoptosis by DNA in situ predicted response with a likelihood ratio of 2.47. These data confirm the role of annexin V and MMP-9 in apoptosis in nephrotic syndrome. The role of MMP-9 in disease progression and that of TIMPs as adjunctive therapy need further elucidation.
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How to cite this article:

Y.H. Kamel, H.M. Bazaraa, A.E. Elwan, N.A. Fahmy and O. Shaker, 2009. Apoptotic Markers in Childhood Nephrotic Syndrome. Journal of Biological Sciences, 9: 509-513.

DOI: 10.3923/jbs.2009.509.513






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