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Journal of Biological Sciences

Year: 2008 | Volume: 8 | Issue: 4 | Page No.: 799-803
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Authors

Tehranipour Maryam

Behnam-Rassouli Morteza

Rahimi Amin

Keywords

Research Article

Maternal Hyperglycemia Proliferate Choroids Plexus and Enlarge the Lateral Ventricle in Brain of Newborn Rats

Tehranipour Maryam, Behnam-Rassouli Morteza and Rahimi Amin
It is well known that structural and functional alterations of microvascular systems are responsible for the most devastating complications of diabetic patients. Alterations of electrolyte composition of CSF in hyperglycemic condition may reflect the microvascular deleterious of choroid plexus. In the present study it is examined the effects of maternal hyperglycemia on the microvascular structure of choroid plexus and the volume of lateral ventricle in newborn Wistar rats. At 7th day of pregnancy hyperglycemia was induced by a single injection (i.p.) of streptozotocin (55 mg kg-1). Control animals were given an equal volume of citrate buffer. After parturition 2 pups were randomly selected from each litter, their brain dissected, fixed in 10% formalin, sectioned in 7 μm thickness and stained by H.E. By applying stereological techniques and systematic random sampling scheme the volume of choroid plexus, length density of capillaries and the volume of the lateral ventricles were estimated. In comparison with controls, statistical analysis showed significant increases (p<0.01) in the length density of capillaries as well as volumes of choroid plexus and lateral ventricle. In conclusion it seems that, similar to the microvascular systems of retina and kidney, the choroid plexus probably is a vulnerable microvascular system in hyperglycemia.
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