Maternal Hyperglycemia Proliferate Choroids Plexus and Enlarge the Lateral Ventricle in Brain of Newborn Rats


	Journal of Biological Sciences
	Year: 2008 \| Volume: 8 \| Issue: 4 \| Page No.: 799-803 DOI: 10.3923/jbs.2008.799.803

Maternal Hyperglycemia Proliferate Choroids Plexus and Enlarge the Lateral Ventricle in Brain of Newborn Rats

Tehranipour Maryam, Behnam-Rassouli Morteza and Rahimi Amin

Abstract: It is well known that structural and functional alterations of microvascular systems are responsible for the most devastating complications of diabetic patients. Alterations of electrolyte composition of CSF in hyperglycemic condition may reflect the microvascular deleterious of choroid plexus. In the present study it is examined the effects of maternal hyperglycemia on the microvascular structure of choroid plexus and the volume of lateral ventricle in newborn Wistar rats. At 7th day of pregnancy hyperglycemia was induced by a single injection (i.p.) of streptozotocin (55 mg kg^-1). Control animals were given an equal volume of citrate buffer. After parturition 2 pups were randomly selected from each litter, their brain dissected, fixed in 10% formalin, sectioned in 7 μm thickness and stained by H.E. By applying stereological techniques and systematic random sampling scheme the volume of choroid plexus, length density of capillaries and the volume of the lateral ventricles were estimated. In comparison with controls, statistical analysis showed significant increases (p<0.01) in the length density of capillaries as well as volumes of choroid plexus and lateral ventricle. In conclusion it seems that, similar to the microvascular systems of retina and kidney, the choroid plexus probably is a vulnerable microvascular system in hyperglycemia.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	The Effect of Curcuma longa Alcoholic Extract on Cell Regeneration (Neurons and Neuroglias) after Sciatic Nerve Injury in Diabetic Rats

How to cite this article:

Tehranipour Maryam, Behnam-Rassouli Morteza and Rahimi Amin, 2008. Maternal Hyperglycemia Proliferate Choroids Plexus and Enlarge the Lateral Ventricle in Brain of Newborn Rats. Journal of Biological Sciences, 8: 799-803.

DOI: 10.3923/jbs.2008.799.803

URL: https://scialert.net/abstract/?doi=jbs.2008.799.803

COMMENT ON THIS PAPER

	Full Name:
	E-mail:
	Comments:

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		AGRICOLA
		AGRIS
		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		EMBASE
		Google Scholar
		SCIMAGO

Follow @scialert

Science Alert